Prednisone and azithromycin.Can You Take Steroids and Antibiotics Together?
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Azithromycin (Oral Route) Precautions - Mayo Clinic
Prednisone and azithromycin
Search for terms. Save this study. Warning You have reached the maximum number of saved studies The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, View this study on Beta. Study Description. Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B.
The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success.
The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will improve out come. Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS. LS will be used to evaluate lymphadenitis at each follow-up visit. The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids.
Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup.
The average household teaspoon may not hold the right amount of liquid. You or your child must take this medicine within 12 hours after it has been mixed with water.
If your child does not use all of the medicine in the bottle, throw it away after you give the dose. Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses.
Your infection may not clear up if you stop using the medicine too soon. These medicines may keep azithromycin from working properly. The dose of this medicine will be different for different patients.
Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.
Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed. It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly.
Blood and urine tests may be needed to check for unwanted effects. If you or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor. This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention.
Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine. Serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms DRESS can occur with this medicine.
Check with your doctor right away if you or your child have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising or unusual tiredness or weakness while you are using this medicine.
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. Published Aug 16, Last updated Aug 16, Answer Thanks so much for reaching out to us and I hope that you are feeling better!
You specifically mentioned azithromycin and prednisone, so I do want to focus on that part. Azithromycin With Prednisone I certainly understand your concern here with taking prednisone. Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely: Common viral infections e.
Staphylococcus aureus Common fungal infections Candida species Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant. Several studies have published results showing preliminary positive benefits with short-term use of the combination: Current evidence suggests that oral corticosteroids as an adjunctive therapy to oral antibiotics are effective for short-term relief of symptoms in acute sinusitis The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection.
Final Words Thanks for your question and please feel free to reach back out in the future! Was this article helpful? About the Pharmacist Dr. Brian Staiger, PharmD Dr. Still Confused? Ask the pharmacist a question here! Recent Questions. Nov 17, We'll never share your email with anyone else.
Drug information provided by: IBM Micromedex. Azithromycin is used to treat certain bacterial infections in many different parts of the body. This medicine may mask or delay the symptoms of syphilis. It is not effective against syphilis infections. Azithromycin belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.
For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of azithromycin to treat sinusitis in children or to treat pneumonia in children younger than 6 months of age. Safety and efficacy have not been established. Appropriate studies have not been performed on the relationship of age to the effects of azithromycin oral suspension and tablets to treat pharyngitis or tonsillitis in children younger than 2 years of age.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of azithromycin in the elderly. However, elderly patients are more likely to have heart rhythm problems eg, torsades de pointes which may require caution in patients receiving azithromycin. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended.
Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. You or your child must take this medicine within 12 hours after it has been mixed with water. If your child does not use all of the medicine in the bottle, throw it away after you give the dose.
Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. These medicines may keep azithromycin from working properly. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.
The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.
Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed. It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly.
Blood and urine tests may be needed to check for unwanted effects. If you or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor. This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention.
Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine.
Serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms DRESS can occur with this medicine. Check with your doctor right away if you or your child have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising or unusual tiredness or weakness while you are using this medicine.
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Call your child's doctor right away if your child feels irritable or vomits after feeding. These may be symptoms of a condition called infantile hypertrophic pyloric stenosis.
Azithromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer.
If you or your child have any questions about this or if mild diarrhea continues or gets worse, check with your doctor. This medicine can cause changes in heart rhythms, including QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you or your child have any symptoms of heart rhythm problems, including fast, pounding, or irregular heartbeats.
This medicine may increase the risk of serious heart or blood vessel problems. Call your doctor right away if you have blurred vision, chest pain, confusion, lightheadedness, dizziness, fainting, fast or irregular heartbeat, trouble breathing, or unusual tiredness or weakness. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
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The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will. Prednisone, a corticosteroid, can suppress the immune system and. Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. Pirfenidone and azithromycin added to prednisolone may have led to clinical and Corticosteroids have anti-inflammatory action and are effective in the. Dear Dr. Roach: In late spring of , I had a sinus infection and was prescribed both an antibiotic and prednisone. About the Pharmacist Dr. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Listing a study does not mean it has been evaluated by the U. Reprint Permissions A single copy of these materials may be reprinted for noncommercial personal use only.Study record managers: refer to the Data Element Definitions if submitting registration or results information. Bartonella henselae is the etiologic agent of cat scratch disease CSD. In most CSD cases resolution occurs in 2 to 3 months although a prolonged course often occurs. Data on the efficacy of antibiotic therapy in CSD is limited.
Azithromycin has been shown to have a small favorable effect in a small comparative study and is commonly prescribed for CSD, however its overall effect is not satisfactory. Corticosteroids may be effective in the treatment of CSD for the following reasons:. The total score will consist of the arithmetical summation of the 5 parameters. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms. Save this study. Warning You have reached the maximum number of saved studies The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.
Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, View this study on Beta.
Study Description. Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B.
The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success.
The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will improve out come.
Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS. LS will be used to evaluate lymphadenitis at each follow-up visit.
The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids. Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate.
FDA Resources. Arms and Interventions. Intervention Details: Drug: prednison and azithromycin Patients with typical cat-scratch disease will be treated with a 5-day course of prednison and azithromycin. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Ability and willingness to comply with the protocol. Male and female patients aged years at the time of signing informed consent.
Patients with clinical manifestations consistent with early typical cat scratch disease lymphadenitis before spontaneous improvement has been recorded and before development of suppuration. Known history of allergy, hypersensitivity, or any serious reaction to azithromycin, other macrolides or corticosteroids. Patients for whom azithromycin or corticosteroids is contra-indicated. Current treatment with systemic corticosteroids.
Patients with typical late cat scratch disease who has demonstrated constant improvement in the clinical manifestations of the involved lymph node. Atypical cat scratch disease e. Endocarditis due to Bartonella sp.. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding. History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography.
Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past. Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Cat-scratch Disease Bartonella Infections. Drug: prednison and azithromycin Drug: prednison, azithromycin Drug: prednison, Azenil.
Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. November 10, Key Record Dates.
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